杨志

一、个人简介

杨志，男，中共党员，博士，硕士生导师。2009年本科毕业于湘潭大学生物工程专业，2015年博士毕业于浙江大学植物学专业，现就职于西北农林科技大学化学与药学院。

二、科研课题

1.国家青年科学基金项目 基于靶向微管的八角莲双黄酮先导化合物的发现及作用机制研究（31800289）25.00万元

2.陕西省专项配套经费 八角莲中新型双黄酮的逆流色谱分离以及抗肿瘤活性评价5.00万元

3.西北农林科技大学博士科研启动费 利用活性指导的逆流色谱分离技术以及LC-MS技术快速寻找和鉴定几种陕西特色中药中的生物活性成分 20.00万元

4.中央高校基本科研业务费 全氟羧酸类和磺酸盐类离子对逆流色谱新方法的建立及其应用研究 10.00万元

三、研究方向

1.天然产物的分离纯化方法学构建及化学成分的活性评价；

2.代谢组学研究

四、开设课程

《无机及分析化学》、《仪器分析综合训练》、《天然产物化学实验》

五、主要科研成果与学术论文

Lanjie Li, Yao Yu, Dini Lu, Jiangxian Chen, Jinxing Guo, Junling, Liang, Anling Zhang, Zhi Yang*. Bioassay-guided separation and identification of the anticancer composition from Curcuma longa L. by the combination strategy of methanol gradient countercurrent chromatography and ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry. Journal of Separation Science , 2022; 45: 4478–4490.

Zhi Yang*, Peipei Guo, Rui Han, Dingfang Wu, Jin-Ming Gao, Shihua Wu. Methanol linear gradient counter-current chromatography for the separation of natural products: Sinopodophyllum hexandrum as samples. Journal of Chromatography A, 1603 (2019) 251–261

Zhi Yang*,Wen-Jia Dan*,Yi-Xiao Li,Guang-Rui Peng,An-Ling Zhang,Jin-Ming Gao. Antifungal metabolites from Alternaria atrans : An endophytic fungus in Psidium guajava Natural Product Communications , 2019,1-5

Yang Zhi*, Guo Peipei, Han Rui, Gao Jinming. Preparative separation of flavone dimers from Dysosma versipellis by countercurrent chromatography: Trifluoroacetic acid as a solvent system modifier. Journal of Separation Science , 2018, 1: 144-153

Yang Zhi*, Guo Peipei, Han Rui, Wu Shihua, Gao Jinmimg. Gram-scale separation of borneol and camphor from Cinnamomum camphora (L.) Presl by continuous counter-current chromatography. Separation Science plus 2018, 1: 144-153

Yang Zhi*, Hu Xueqian, Wu Shihua. Preparative isolation of a cytotoxic principle of a forest mushroom Suillus luteus by sodium dodecyl sulfate based "salting-in" countercurrent chromatography. Journal of Separation Science , 2016, 39(4): 732-740

Yang Zhi*, Wu Youqian, Wu Shihua. A combination strategy for extraction and isolation of multi-component natural products by systematic two-phase solvent extraction-C-13 nuclear magnetic resonance pattern recognition and following conical counter-current chromatography separation: Podophyllotoxins and flavonoids from Dysosma versipellis (Hance) as examples. Journal of Chromatography A , 2016, 1431: 184-196

Yang, Zhi*, Wu Youqian, Zhou Hui,Cao Xiaoji, Jiang Xinhang, Wang Kuiwu, Wu Shihua. A novel strategy for screening new natural products by a combination of reversed-phase liquid chromatography fractionation and C-13 NMR pattern recognition: the discovery of new anti-cancer flavone dimers from Dysosma versipellis (Hance). Rsc Advances , 2015, 5(95): 77553-77564

Yang Zhi*, Liu Xiaoman, Wang Kuiwu, Cao Xiaoji, Wu Shihua. Novel linear and step-gradient counter-current chromatography for bio-guided isolation and purification of cytotoxic podophyllotoxins from Dysosma versipellis (Hance). Journal of Separation Science, 2013, 36(6): 1022-1028

Meng Jie, Yang Zhi, Liang Junling, Guo Mengzhe, Wu Shihua. Multi-channel recycling counter-current chromatography for natural productisolation: Tanshinones as examples. Journal of Chromatography A , 2014, 1327: 27-38

Meng Jie, Yang Zhi, Liang Junling, Zhou Hui, Wu Shihua. Comprehensive multi-channel multi-dimensional counter-current chromatography for separation of tanshinones from Salvia miltiorrhiza Bunge, Journal of Chromatography A, 2014, 1323: 73-81

Liang Junling, Meng Jie, Guo Mengzhe, Yang Zhi, Wu Shihua. Conical coils counter-current chromatography for preparative isolation and purification of tanshinones from Salvia miltiorrhiza Bunge. Journal of Chromatography A , 2013, 1288: 35-39

Liang Junling, Yang Zhi, Cao Xiaoji, Wu Bing, Wu Shihua. Preparative isolation of novel antioxidant flavonoids of alfalfa by stop-and-go counter-current chromatography and following on-line liquid chromatography desalination. Journal of Chromatography A, 2011, 1218(36): 6191-6199

六、联系方式

通讯地址：陕西杨凌西农路22号 西北农林科技大学化学与药学院

邮编：712100

电话：13772512177

邮箱：muyiyuanzhi@nwafu.edu.cn